A suicidal American befriends a Japanese man lost in a forest near Mt. Fuji and the two search for a way out.

When virtually all of the residents of Piedmont, New Mexico, are found dead after the return to Earth of a space satellite, the head of the US Air Force's Project Scoop declares an emergency. A group of eminent scientists led by Dr. Jeremy Stone scramble to a secure laboratory and try to first isolate the life form while determining why two people from Piedmont - an old alcoholic and a six-month-old baby - survived. The scientists methodically study the alien life form unaware that it has already mutated and presents a far greater danger in the lab, which is equipped with a nuclear self-destruct device designed to prevent the escape of dangerous biological agents..

In New York, the boys Rocky Sullivan and Jerry Connelly are best friends and small time thieves. After a robbery, Rocky is arrested and sent to a reformatory school, where he begins his criminal career. Jerry escapes and later becomes a priest. After three years in prison, Rocky is released and demands the return of $100,000 deposited with his Solicitor - prior to his jail term.

In 1863, Mississippi farmer Newt Knight serves as a medic for the Confederate Army. Opposed to slavery, Knight would rather help the wounded than fight the Union. After his nephew dies in battle, Newt returns home to Jones County to safeguard his family but is soon branded an outlaw deserter. Forced to flee, he finds refuge with a group of runaway slaves hiding out in the swamps. Forging an alliance with the slaves and other farmers, Knight leads a rebellion that would forever change history.