On a small town college campus, a philosophy professor in existential crisis gives his life new purpose when he enters into a relationship with his student.

A man who runs an apartment house for women is the demented son of a Nazi surgeon who has the house equipped with secret passageways, hidden rooms and torture and murder devices.

Chrissie and her friends set out on a road trip for a final fling before one is shipped off to Vietnam. Along the way, bikers harass the foursome and cause an accident that throws Chrissie from the vehicle. The lawman who arrives on the scene kills one of the bikers and brings Chrissie's friends to the Hewitt homestead, where young Leatherface is learning the tools of terror.

Years after the Racoon City catastrophe, survivors travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against hordes of zombies and the evil Umbrella Corp.