Theron proved her comedy chops in the underrated Young Adult, and here she and MacFarlane get along like two eager puppies. If MacFarlane indulges in self-flattery by keeping in all the times this babe bursts into laughter at his jokes, he's forgiven; at least we feel like the characters are actually listening to each other.

In A Million Ways to Die in the West, MacFarlane loads up enough zaniness to make for a generally enjoyable mashup, particularly because the genial plot affords him a solid backdrop.

Despite the constant threat of untimely death, though, the consequences never seem too dire, and MacFarlane’s irreverent humor feels subdued without the jolt of animation that gave his previous big-screen effort, "Ted," an extra oomph of shock and awe.

The moments of absurdity land with a wonderfully weird grace, while the desperately vulgar gags about sex and scatology echo and crash as though they were being uttered in a middle-school boys’ restroom.

A Million Ways To Die In The West certainly has merits, and in some ways, it is a step forward for MacFarlane, but it is also deeply undisciplined, and it undercuts its own best instincts in ways I find almost unbearably frustrating.